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Which outcome impedes protein folding relying on water?

A)Hydrophobic effect minimizes water contact
B)Disulfide bridges promote rigid structures
C)Peptide bonds maximize chain flexibility
D)Salt bridges enhance ionic interactions

💡 Explanation

Protein folding slows when incorrectly hydrated surfaces cluster because the hydrophobic effect excludes water molecules, hindering proper protein conformation. Therefore, non-native aggregation reduces folding efficiency, rather than disulfide bridge formation or peptide / salt bridge strength alterations.

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