Which outcome is most likely when molecular mimicry bypasses thymic selection and regulatory T cell (Treg) activity is insufficient after a Streptococcus infection?

💡 Explanation

Autoimmune rheumatic fever arises because molecular mimicry between streptococcal antigens and cardiac tissue can activate self-reactive T cells. Insufficient Treg activity fails to suppress these autoreactive cells, therefore autoimmunity develops, rather than pathogen clearance or immune suppression which require effective, not misdirected, immune regulation.

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