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← ScienceWhich outcome occurs when an enzyme's active site conformation changes in a biochemical pathway?
A)Decreased reaction rate overall✓
B)Increased substrate binding affinity
C)Transition state shifts
D)Lowered activation energy barrier
💡 Explanation
A conformational change disrupts the enzyme-substrate complex, therefore *enzyme inhibition* results because the active site's optimal fit is distorted, rather than enhancing binding affinity or directly reducing activation energy.
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