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Which risk increases when asymmetric molecular bond breakage occurs during drug metabolism?

A)Increased therapeutic effect efficacy
B)Formation of toxic metabolites
C)Enhanced drug bioavailability occurs
D)Reduced cytochrome P450 inhibition

💡 Explanation

The formation of toxic metabolites increases because heterolytic cleavage, a type of asymmetric bond breakage, results in unequal electron distribution, promoting reactive electrophiles, rather than favoring stable products, therefore leading to toxicity under physiological conditions.

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