Why does administering a high dose of non-selective NSAIDs, like ibuprofen, increase the risk of gastrointestinal ulcer formation, even when mucus production remains relatively stable?

💡 Explanation

NSAIDs inhibit cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis. Because prostaglandins stimulate mucus and bicarbonate secretion and inhibit gastric acid, their absence compromises mucosal protection. Therefore, ulcer risk increases due to decreased mucosal defense, rather than altered acid neutralization or cell proliferation.

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