Why does asthma-induced bronchoconstriction worsen upon allergen exposure, even with a beta-agonist inhaler?

💡 Explanation

Asthma worsens with allergens due to uncontrolled histamine release from mast cells. Beta-agonists primarily relax bronchial smooth muscle, but cannot fully counteract the inflammatory cascade initiated by histamine because mast cell degranulation is unchecked, therefore the inflammatory response dominates, rather than bronchodilation alone.

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