Why does cancellous bone density decrease more rapidly than cortical bone density in postmenopausal women undergoing estrogen reduction?

💡 Explanation

Cancellous bone undergoes more rapid density loss because it has a higher surface area and metabolic activity, therefore a greater remodeling rate. The increased bone turnover amplifies the effects of estrogen reduction on osteoclast activity and bone resorption, rather than altering osteoclast apoptosis.

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