If a patient has a genetic defect causing decreased fibrinogen production, why does platelet aggregation become impaired?

💡 Explanation

Platelet aggregation depends on fibrinogen binding to platelet receptors to form fibrin bridges between platelets. Reduced fibrinogen impairs this mechanism, because platelets cannot effectively cross-link to create a stable plug. Therefore, aggregation is impaired, rather than proceeding normally or being related to calcium or vWF.

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