Why does chronic exposure during allergen-specific immunotherapy gradually reduce allergic responses in sensitized individuals?

💡 Explanation

Allergen-specific immunotherapy leads to the induction of T-regulatory cells, which promotes a shift from IgE to IgG4 antibody production; because IgG4 competes with IgE for allergen binding, mast cell degranulation and histamine release are reduced. Therefore, allergic responses diminish, rather than eosinophil degradation or basophil neutralization.

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