Why does chronic graft-versus-host disease (cGVHD) often involve persistent inflammation and fibrosis after donor lymphocyte infusion?

💡 Explanation

cGVHD involves immune dysregulation where donor T-cells react against host tissues, leading to cytokine storm and inflammation. This persistent inflammation promotes fibroblast activation and fibrosis, because the initial immune assault sets up a positive feedback loop. Therefore, chronic inflammation and fibrosis occur, rather than immune tolerance or tissue repair.

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