Why does chronic hypertension, despite increased arterial pressure, sometimes fail to suppress aldosterone release effectively?

💡 Explanation

Chronic hypertension can lead to structural and functional changes in the renin-angiotensin-aldosterone system (RAAS). Because chronic pressure elevation can upregulate angiotensin II receptors in the adrenal glands, aldosterone secretion persists despite high blood pressure; therefore, angiotensin sensitivity becomes upregulated, rather than other mechanisms inhibiting release.

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