Why does chronic traumatic encephalopathy (CTE) development become more likely with repeated concussions?

💡 Explanation

CTE arises from the progressive accumulation of hyperphosphorylated tau protein aggregates, because repeated concussions impair the proteasomal and autophagy pathways responsible for clearing these aggregates. Therefore, CTE becomes likely, rather than the astrocytes cleaving amyloid precursor protein, microglia overwhelming tissue, or blood-brain barrier integrity improving.

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