Why does elevated estrogen during the menstrual cycle typically promote follicle maturation, rather than follicular atresia, despite both processes using similar receptors?

💡 Explanation

Elevated estrogen levels during the menstrual cycle upregulate LH receptors on thecal cells; this is because, rather than a direct effect on the follicles, estrogen's primary effect is to stimulate LH receptor expression which supports further androgen production. Therefore, this positive feedback supports follicle maturation, rather than directly causing atresia.

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