Why does GLP-1 receptor agonism promote weight loss in type 2 diabetics, differing from insulin's frequent association with weight gain?

💡 Explanation

GLP-1 receptor agonists increase satiety and decrease appetite by activating GLP-1 receptors on vagal afferents that project to the brain, which reduces food intake. Therefore, weight loss occurs because appetite is suppressed, rather than through direct effects on fat absorption or thyroid hormones.

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