During intense exercise, muscle tissue produces lactic acid. What causes hemoglobin's oxygen affinity to decrease in exercising muscle tissue?

💡 Explanation

The Bohr effect explains decreased oxygen affinity due to increased acidity from lactic acid; this increases 2,3-BPG levels in erythrocytes. This allosteric modulator stabilizes the T-state of hemoglobin, reducing oxygen affinity, because this facilitates oxygen release to highly active muscle tissue rather than retaining it. Therefore, 2,3-BPG concentration increases explain hemoglobin's oxygen affinity decrease.

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