Why does mutant huntingtin protein clearance via autophagy decline in Huntington's disease?

💡 Explanation

mTOR activation suppresses autophagy by inhibiting the ULK1 complex, which is essential for autophagosome formation; because mTOR is hyperactive in Huntington's disease, it impairs mutant huntingtin clearance. Therefore, autophagy is less effective, rather than phagocytosis or proteasome activity being the primary issue.

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