Why does neuronal damage continue even after initial amyloid plaque formation stops in some neurodegenerative diseases?

💡 Explanation

Neurons continue to degrade because, even when amyloid plaque formation plateaus, intracellular tau protein aggregates can propagate via impaired autophagy. The proteasomal degradation pathway is compromised, leading to a build-up of these toxic aggregates. Therefore, continued neuronal damage arises from this spread, rather than the direct impact of amyloid plaques or the other options.

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