Why does neuronal damage continue in some neurodegenerative diseases even after the initial triggering event?

💡 Explanation

Misfolded proteins, like amyloid-beta or tau, can aggregate and act as seeds, inducing further misfolding and aggregation of native proteins; this process is known as seeding. Because of this prion-like propagation mechanism, protein aggregation continues, therefore damage persists, rather than halting, even after the initial trigger is removed.

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