Why does neuronal loss in Alzheimer's disease disproportionately affect memory, rather than other cognitive functions early on?

💡 Explanation

Alzheimer's disease initially impairs memory disproportionately because neurofibrillary tangles composed of hyperphosphorylated tau protein accumulate first in the hippocampus, a brain region critical for memory consolidation. Therefore, memory is affected earlier rather than other functions, because tau aggregation targets this region first.

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