Why does persistent signaling via the NF-κB pathway, activated by inflammatory cytokines, increase the risk of tumor development in tissues experiencing chronic inflammation?

💡 Explanation

NF-κB activation by cytokines leads to increased expression of anti-apoptotic proteins and pro-proliferation factors; because NF-κB regulates genes involved in cell survival and division, its persistent activation promotes uncontrolled cell growth. Therefore, the risk of tumor development rises, rather than cell cycle arrest, DNA repair, or antioxidant responses mitigating the effect.

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