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Human Body & Health

Why does prolonged exposure to UVB radiation suppress the immune system more in lightly pigmented skin compared to darkly pigmented skin?

A)Melanin decreases Langerhans cell migration
B)Melanin stimulates immunosuppressive cytokine release
C)Melanin enhances T-regulatory cell production directly
D)Melanin absorbs UVB, limiting DNA damage

💡 Explanation

Melanin absorbs UVB radiation, which prevents DNA damage and subsequent release of immunosuppressive factors. Therefore, lightly pigmented skin is more susceptible to immune suppression because less melanin is available to block the radiation, rather than melanin directly affecting immune cells.

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