If a drug has a high volume of distribution and lipophilicity, which consequence follows a standard dose administration?

💡 Explanation

A high volume of distribution means the drug extensively distributes into tissues rather than remaining in the plasma; because lipophilic drugs easily cross cell membranes and accumulate in fatty tissues, this sequestration reduces the amount of drug available for elimination, therefore extending the half-life, rather than affecting excretion, metabolism, or plasma concentration directly.

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