Why does prolonged pressure on a nerve, such as sitting with legs crossed, lead to numbness and tingling sensations distal to the compression point?

💡 Explanation

Prolonged pressure impairs axonal transport and restricts blood flow, leading to ischemia in the nerve because of mechanical compression. This disrupts the nerve's ability to transmit signals properly, therefore numbness and tingling occur, rather than increased nerve firing or synaptic changes.

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