Why does pulsatile GnRH secretion improve fertility outcomes compared to continuous GnRH administration during assisted reproductive technology?

💡 Explanation

Pulsatile GnRH prevents downregulation of GnRH receptors in the pituitary gland, because continuous stimulation leads to receptor desensitization and reduced gonadotropin release. Therefore, pulsatile administration maintains receptor sensitivity, rather than causing desensitization or only affecting estrogen.

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