Why does skeletal fragility increase post-menopause even with adequate dietary calcium?

💡 Explanation

Post-menopause, estrogen levels decline, reducing osteoblast stimulation and increasing osteoclast activity; this leads to a decrease in bone mineral density because estrogen's bone-protective effects are diminished, therefore skeletal fragility increases, rather than being countered by increased calcium reabsorption or calcitonin.

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