Why does the gut hormone Glucagon-Like Peptide-1 (GLP-1) reduce appetite following gastric bypass surgery in obese patients?

💡 Explanation

Gastric bypass enhances GLP-1 secretion because the altered nutrient flow stimulates intestinal L-cells, which release GLP-1. Therefore, appetite is suppressed due to increased satiety signals to the brain, rather than solely due to mechanical restriction or malabsorption.

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