Why does the risk of neurodegenerative diseases, such as Alzheimer's, increase with age concerning amyloid-beta plaques and tau protein tangles?

💡 Explanation

The risk increases because the efficiency of autophagy, the process responsible for clearing misfolded proteins and damaged organelles, declines with age. Therefore, toxic protein aggregates like amyloid-beta and tau accumulate, leading to neurodegeneration, rather than a direct overproduction of neurotransmitters or impermeable blood-brain barrier.

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