Why does unchecked growth proceed despite DNA damage in some cancers with mutated growth factor receptors, evading normal apoptotic triggers?

💡 Explanation

Cancer cells often evade apoptosis due to growth factor receptor mutations leading to the constitutive activation of anti-apoptotic pathways like PI3K/Akt, because this override normal checkpoint controls. Therefore, unchecked growth ensues, rather than cell cycle arrest or programmed cell death triggered by DNA damage.

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