A researcher investigates rheumatoid arthritis treatments by blocking specific cytokines. If TNF-α signaling is successfully suppressed, which consequence becomes most pronounced?

💡 Explanation

Blocking TNF-α inhibits its pro-inflammatory role in positive feedback loops, therefore reducing the amplification of inflammatory signals via other cytokines. This occurs because TNF-α activates NF-κB, leading to the transcription of more inflammatory cytokines, rather than directly affecting cartilage or osteoclasts.

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