If a drug with high lipophilicity and a large volume of distribution is administered intravenously but the patient has hypoalbuminemia, which consequence follows regarding the drug's free concentration?

💡 Explanation

Increased free drug concentration will result because the drug typically binds to albumin, and hypoalbuminemia reduces this binding capacity, therefore the unbound (free) fraction increases, rather than remaining unchanged or decreasing due to altered metabolism or excretion.

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