If a long-distance runner abruptly stops training, which skeletal change is most likely due to altered osteocyte signaling within bone remodeling?

💡 Explanation

Reduced mechanical loading from ceasing training decreases the Piezo1-mediated signaling in osteocytes, inhibiting bone formation by osteoblasts and promoting bone resorption by osteoclasts, therefore trabecular bone volume decreases. This occurs because bone adapts to mechanical stress, rather than maintaining density in the absence of stress, and thus bone loss occurs.

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