Why does anaphylaxis typically worsen with repeated exposure to the same allergen, rather than remaining constant?

A)Decreased mast cell histamine synthesis

B)T-cell exhaustion reduces immune response

C)Increased IgE sensitization of mast cells✓

D)B-cell tolerance induction limits antibodies

💡 Explanation

Anaphylaxis worsens due to increased IgE sensitization of mast cells because initial exposure primes the immune system to produce IgE antibodies specific to the allergen. Therefore, subsequent exposures trigger a more rapid and amplified mast cell degranulation and histamine release, rather than a constant or diminished response due to tolerance or exhaustion.

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Why does anaphylaxis typically worsen with repeated exposure to the same allergen, rather than remaining constant?

💡 Explanation

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