If a stroke patient arrives at the ER outside the tPA window, but demonstrates a large penumbral region on perfusion imaging, which intervention strategy faces increased risk?

💡 Explanation

Rapid reperfusion carries increased risk because hemorrhagic transformation becomes more likely when ischemic tissue, particularly in the penumbra, is suddenly re-perfused after prolonged ischemia; therefore, controlled reperfusion is favored rather than aggressive, because the blood-brain barrier is already compromised.

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