If aggregated alpha-synuclein proteins accumulate within dopaminergic neurons of the substantia nigra, which consequence follows?

💡 Explanation

The formation of alpha-synuclein aggregates, such as Lewy bodies, disrupts normal cellular function because it impairs protein degradation pathways and mitochondrial function, therefore dopaminergic neuron death occurs leading to progressive motor decline, rather than increased dopamine synthesis or direct astrocyte/microglia-mediated repair.

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