If an Rh-negative pregnant woman carrying an Rh-positive fetus is not treated with Rho(D) immune globulin, which consequence follows during a subsequent pregnancy with another Rh-positive fetus?

💡 Explanation

Without Rho(D) immune globulin, the mother's immune system can become sensitized to the Rh antigen; therefore, maternal anti-Rh antibodies cross the placenta in subsequent pregnancies, attacking fetal red blood cells and causing hemolytic disease of the fetus and newborn, rather than inducing iron overload or affecting bone marrow directly, because the mechanism is antibody-mediated hemolysis.

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