In Alzheimer's disease, which mechanism explains why extracellular plaques of amyloid-beta protein aggregates disrupt neuronal function?

💡 Explanation

Amyloid-beta aggregates trigger microglial activation, releasing cytokines that promote chronic neuroinflammation and synaptic dysfunction; this is the inflammatory cascade. Therefore, neuroinflammation is the primary disruptive mechanism, rather than direct effects on neurotransmitter reuptake or axonal transport because these are secondary consequences.

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