What causes a delayed sense of satiety after consuming a high-fructose meal compared to a glucose-rich meal?

💡 Explanation

Fructose metabolism largely bypasses GLP-1 stimulation in the gut; because GLP-1 normally signals satiety to the brain, lower release delays that feeling. Therefore, less GLP-1 stimulation delays satiety signals, rather than increased ghrelin, altered leptin, or enhanced insulin sensitivity causing the effect.

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