Why does prolonged neuronal hyperexcitability result in reduced seizure threshold in nervous tissues?

💡 Explanation

Chronic neuronal hyperexcitability leads to increased calcium influx, which triggers homeostatic mechanisms that decrease GABA receptor expression via internalization; because inhibitory signaling is reduced, seizure threshold drops. Therefore, GABA receptor internalization is the correct answer, rather than altered glial cells, neurotransmitter synthesis, or axonal transport.

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