If a patient with central diabetes insipidus receives a dose of a non-selective COX inhibitor like ibuprofen, which consequence becomes likely regarding urine osmolality in the collecting ducts?

💡 Explanation

In central diabetes insipidus, ADH secretion is impaired, leading to reduced water reabsorption. Non-selective COX inhibitors reduce prostaglandin synthesis, which normally inhibits ADH action. Because less prostaglandin is available to inhibit ADH's effect in the collecting ducts, water reabsorption increases, therefore urine osmolality increases, rather than changes driven by altered channel expression or receptor dynamics.

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