Which consequence results when prolonged immobilization affects limb biomechanics?

💡 Explanation

Lowered mechanical stimuli cause increased osteoclast activity during bone remodeling; thereby, bone mineral density decreases. This is Wolff's Law. Cancellous bone is more susceptible rather than cortical bone, because it undergoes more remodeling under normal ambulatory conditions; therefore, lack of loading promotes bone resorption.

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