Which consequence results when reuptake of serotonin is excessively inhibited?

💡 Explanation

Prolonged postsynaptic receptor activation occurs because inhibition of serotonin reuptake prevents the clearance of the neurotransmitter from the synaptic cleft, therefore intensifying and extending its effect on the target neuron, rather than glial involvement.

• A patient requires increasing morphine doses to manage chronic pain following surgery. Which mechanism primarily explains the reduced analgesic effect over time?
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